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stimulation with il33  (Sino Biological)
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Sino Biological stimulation with il33
(A) Crystal structure of IL1RAP (PDB: 4DEP), with IL1 (olive), IL-1RI (grey) and c2d2 loop (blue) interfaces colored. (B) Crystal structure of IL1RAP (PDB: 5VI4), with <t>IL33</t> (cyan), IL-33R (pink) and c2d2 loop (green) interfaces colored. (C) Crystal structure of IL1RAP (PDB: 3O4O), with IL1 (dark goldenrod), IL-1R2 (deep pink) and c2d2 loop (red) interfaces colored. (D) Schematic diagram of antibody discovery and screening workflow. (E) ELISA binding assessment of the parental antibody to full-length IL1RAP and its individual domains.
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csb e14077r 3  (Cusabio)
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Cusabio csb e14077r 3
(A) Crystal structure of IL1RAP (PDB: 4DEP), with IL1 (olive), IL-1RI (grey) and c2d2 loop (blue) interfaces colored. (B) Crystal structure of IL1RAP (PDB: 5VI4), with <t>IL33</t> (cyan), IL-33R (pink) and c2d2 loop (green) interfaces colored. (C) Crystal structure of IL1RAP (PDB: 3O4O), with IL1 (dark goldenrod), IL-1R2 (deep pink) and c2d2 loop (red) interfaces colored. (D) Schematic diagram of antibody discovery and screening workflow. (E) ELISA binding assessment of the parental antibody to full-length IL1RAP and its individual domains.
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inflammation  (Cusabio)
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Cusabio inflammation
(A) Crystal structure of IL1RAP (PDB: 4DEP), with IL1 (olive), IL-1RI (grey) and c2d2 loop (blue) interfaces colored. (B) Crystal structure of IL1RAP (PDB: 5VI4), with <t>IL33</t> (cyan), IL-33R (pink) and c2d2 loop (green) interfaces colored. (C) Crystal structure of IL1RAP (PDB: 3O4O), with IL1 (dark goldenrod), IL-1R2 (deep pink) and c2d2 loop (red) interfaces colored. (D) Schematic diagram of antibody discovery and screening workflow. (E) ELISA binding assessment of the parental antibody to full-length IL1RAP and its individual domains.
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rat interleukin 33  (Cusabio)
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Cusabio rat interleukin 33
(A) Crystal structure of IL1RAP (PDB: 4DEP), with IL1 (olive), IL-1RI (grey) and c2d2 loop (blue) interfaces colored. (B) Crystal structure of IL1RAP (PDB: 5VI4), with <t>IL33</t> (cyan), IL-33R (pink) and c2d2 loop (green) interfaces colored. (C) Crystal structure of IL1RAP (PDB: 3O4O), with IL1 (dark goldenrod), IL-1R2 (deep pink) and c2d2 loop (red) interfaces colored. (D) Schematic diagram of antibody discovery and screening workflow. (E) ELISA binding assessment of the parental antibody to full-length IL1RAP and its individual domains.
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il 33 elisa kit  (Cusabio)
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Cusabio il 33 elisa kit
Relative mRNA expression of inflammatory genes and levels of cytokines in the lung tissue of rats in each group. (A–D) Relative mRNA expressions of Il6, Il1ra, Il1b , and Plaur of lung tissue in the different groups of rats. (E–L) The levels of IL‐6, IL‐1α, IL‐1β, IL‐12p70, <t>IL‐33,</t> IL‐18, TNF‐α, and KC in lung tissue homogenate of rats in three groups were examined. Six rats per group, and data from each group were repeated three times in each experiment. The data were pooled together for analysis. Room air group ( n = 3–6), hyperoxia group ( n = 4–10), hyperoxia with GB treatment group ( n = 5–13).
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csb e07364r rat interleukin 33  (Cusabio)
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Cusabio csb e07364r rat interleukin 33
Relative mRNA expression of inflammatory genes and levels of cytokines in the lung tissue of rats in each group. (A–D) Relative mRNA expressions of Il6, Il1ra, Il1b , and Plaur of lung tissue in the different groups of rats. (E–L) The levels of IL‐6, IL‐1α, IL‐1β, IL‐12p70, <t>IL‐33,</t> IL‐18, TNF‐α, and KC in lung tissue homogenate of rats in three groups were examined. Six rats per group, and data from each group were repeated three times in each experiment. The data were pooled together for analysis. Room air group ( n = 3–6), hyperoxia group ( n = 4–10), hyperoxia with GB treatment group ( n = 5–13).
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csb e14077r  (Cusabio)
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Cusabio csb e14077r
Relative mRNA expression of inflammatory genes and levels of cytokines in the lung tissue of rats in each group. (A–D) Relative mRNA expressions of Il6, Il1ra, Il1b , and Plaur of lung tissue in the different groups of rats. (E–L) The levels of IL‐6, IL‐1α, IL‐1β, IL‐12p70, <t>IL‐33,</t> IL‐18, TNF‐α, and KC in lung tissue homogenate of rats in three groups were examined. Six rats per group, and data from each group were repeated three times in each experiment. The data were pooled together for analysis. Room air group ( n = 3–6), hyperoxia group ( n = 4–10), hyperoxia with GB treatment group ( n = 5–13).
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csbe13000h  (Cusabio)
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Cusabio csbe13000h
Relative mRNA expression of inflammatory genes and levels of cytokines in the lung tissue of rats in each group. (A–D) Relative mRNA expressions of Il6, Il1ra, Il1b , and Plaur of lung tissue in the different groups of rats. (E–L) The levels of IL‐6, IL‐1α, IL‐1β, IL‐12p70, <t>IL‐33,</t> IL‐18, TNF‐α, and KC in lung tissue homogenate of rats in three groups were examined. Six rats per group, and data from each group were repeated three times in each experiment. The data were pooled together for analysis. Room air group ( n = 3–6), hyperoxia group ( n = 4–10), hyperoxia with GB treatment group ( n = 5–13).
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tslp cat e el h1598  (Elabscience Biotechnology)
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Elabscience Biotechnology tslp cat e el h1598
Relative mRNA expression of inflammatory genes and levels of cytokines in the lung tissue of rats in each group. (A–D) Relative mRNA expressions of Il6, Il1ra, Il1b , and Plaur of lung tissue in the different groups of rats. (E–L) The levels of IL‐6, IL‐1α, IL‐1β, IL‐12p70, <t>IL‐33,</t> IL‐18, TNF‐α, and KC in lung tissue homogenate of rats in three groups were examined. Six rats per group, and data from each group were repeated three times in each experiment. The data were pooled together for analysis. Room air group ( n = 3–6), hyperoxia group ( n = 4–10), hyperoxia with GB treatment group ( n = 5–13).
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mouse il 33  (Elabscience Biotechnology)
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Elabscience Biotechnology mouse il 33
Relative mRNA expression of inflammatory genes and levels of cytokines in the lung tissue of rats in each group. (A–D) Relative mRNA expressions of Il6, Il1ra, Il1b , and Plaur of lung tissue in the different groups of rats. (E–L) The levels of IL‐6, IL‐1α, IL‐1β, IL‐12p70, <t>IL‐33,</t> IL‐18, TNF‐α, and KC in lung tissue homogenate of rats in three groups were examined. Six rats per group, and data from each group were repeated three times in each experiment. The data were pooled together for analysis. Room air group ( n = 3–6), hyperoxia group ( n = 4–10), hyperoxia with GB treatment group ( n = 5–13).
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Image Search Results


(A) Crystal structure of IL1RAP (PDB: 4DEP), with IL1 (olive), IL-1RI (grey) and c2d2 loop (blue) interfaces colored. (B) Crystal structure of IL1RAP (PDB: 5VI4), with IL33 (cyan), IL-33R (pink) and c2d2 loop (green) interfaces colored. (C) Crystal structure of IL1RAP (PDB: 3O4O), with IL1 (dark goldenrod), IL-1R2 (deep pink) and c2d2 loop (red) interfaces colored. (D) Schematic diagram of antibody discovery and screening workflow. (E) ELISA binding assessment of the parental antibody to full-length IL1RAP and its individual domains.

Journal: bioRxiv

Article Title: Anti-IL1RAP Antibodies for Pan-Inhibition of IL-1 Family Cytokine Signaling in Inflammatory Diseases and Oncology

doi: 10.64898/2026.02.13.705739

Figure Lengend Snippet: (A) Crystal structure of IL1RAP (PDB: 4DEP), with IL1 (olive), IL-1RI (grey) and c2d2 loop (blue) interfaces colored. (B) Crystal structure of IL1RAP (PDB: 5VI4), with IL33 (cyan), IL-33R (pink) and c2d2 loop (green) interfaces colored. (C) Crystal structure of IL1RAP (PDB: 3O4O), with IL1 (dark goldenrod), IL-1R2 (deep pink) and c2d2 loop (red) interfaces colored. (D) Schematic diagram of antibody discovery and screening workflow. (E) ELISA binding assessment of the parental antibody to full-length IL1RAP and its individual domains.

Article Snippet: Cells were treated with escalating concentrations of DXP-006, DXP-106, or antagonists as indicated, followed by stimulation with IL33 (Sinobiological, 10368-HNAE) or IL1α+IL1β+IL33 at their respective pre-determined EC 80 .

Techniques: Enzyme-linked Immunosorbent Assay, Binding Assay

(A-B) Inhibition of IL1α (A) and IL1β (B) induced signaling by indicated antibodies in HEK-Blue IL-1 reporter cells. (C) Inhibition of IL33 induced signaling by indicated antibodies in HUVEC cells. (D) Inhibition of IL1α, IL1β, and IL33 induced signaling by indicated antibodies in HUVEC cells. (E-G) Inhibition of IL36α (E), IL36β (F) and IL36γ (G) induced signaling by indicated antibodies in A431 cells. (H) Inhibition of IL1α, IL1β, IL36α, IL36β, and IL36γ induced signaling by indicated antibodies in A431 cells.

Journal: bioRxiv

Article Title: Anti-IL1RAP Antibodies for Pan-Inhibition of IL-1 Family Cytokine Signaling in Inflammatory Diseases and Oncology

doi: 10.64898/2026.02.13.705739

Figure Lengend Snippet: (A-B) Inhibition of IL1α (A) and IL1β (B) induced signaling by indicated antibodies in HEK-Blue IL-1 reporter cells. (C) Inhibition of IL33 induced signaling by indicated antibodies in HUVEC cells. (D) Inhibition of IL1α, IL1β, and IL33 induced signaling by indicated antibodies in HUVEC cells. (E-G) Inhibition of IL36α (E), IL36β (F) and IL36γ (G) induced signaling by indicated antibodies in A431 cells. (H) Inhibition of IL1α, IL1β, IL36α, IL36β, and IL36γ induced signaling by indicated antibodies in A431 cells.

Article Snippet: Cells were treated with escalating concentrations of DXP-006, DXP-106, or antagonists as indicated, followed by stimulation with IL33 (Sinobiological, 10368-HNAE) or IL1α+IL1β+IL33 at their respective pre-determined EC 80 .

Techniques: Inhibition

(A) Cryo-EM map of the complex that contains DXP-006 (purple and pink), IL1RAP (cyan; domain 2 and domain 3) and density map (grey), c2d2 loop (blue density map). (B) Interfaces between DXP-006 and IL1RAP. (C) Crystal structure of IL1RAP with the DXP-006 Interface (cyan) and CAN10 interface (blue). (D) Crystal structure of IL1RAP domain 2 and domain 3 (PDB:4DEP), colored with IL-1 (yellow), IL33 (orange), IL-36 (green) and DXP-006 (cyan) interface.

Journal: bioRxiv

Article Title: Anti-IL1RAP Antibodies for Pan-Inhibition of IL-1 Family Cytokine Signaling in Inflammatory Diseases and Oncology

doi: 10.64898/2026.02.13.705739

Figure Lengend Snippet: (A) Cryo-EM map of the complex that contains DXP-006 (purple and pink), IL1RAP (cyan; domain 2 and domain 3) and density map (grey), c2d2 loop (blue density map). (B) Interfaces between DXP-006 and IL1RAP. (C) Crystal structure of IL1RAP with the DXP-006 Interface (cyan) and CAN10 interface (blue). (D) Crystal structure of IL1RAP domain 2 and domain 3 (PDB:4DEP), colored with IL-1 (yellow), IL33 (orange), IL-36 (green) and DXP-006 (cyan) interface.

Article Snippet: Cells were treated with escalating concentrations of DXP-006, DXP-106, or antagonists as indicated, followed by stimulation with IL33 (Sinobiological, 10368-HNAE) or IL1α+IL1β+IL33 at their respective pre-determined EC 80 .

Techniques: Cryo-EM Sample Prep

(A-B) Inhibition of IL1α (A) and IL1β (B) induced signaling by indicated antibodies in HEK-Blue IL-1 reporter cells. (C) Inhibition of IL33 induced signaling by indicated antibodies in HUVEC cells. (D-F) Inhibition of IL36α (D), IL36β (E) and IL36γ (F) induced signaling by indicated antibodies in A431 cells.

Journal: bioRxiv

Article Title: Anti-IL1RAP Antibodies for Pan-Inhibition of IL-1 Family Cytokine Signaling in Inflammatory Diseases and Oncology

doi: 10.64898/2026.02.13.705739

Figure Lengend Snippet: (A-B) Inhibition of IL1α (A) and IL1β (B) induced signaling by indicated antibodies in HEK-Blue IL-1 reporter cells. (C) Inhibition of IL33 induced signaling by indicated antibodies in HUVEC cells. (D-F) Inhibition of IL36α (D), IL36β (E) and IL36γ (F) induced signaling by indicated antibodies in A431 cells.

Article Snippet: Cells were treated with escalating concentrations of DXP-006, DXP-106, or antagonists as indicated, followed by stimulation with IL33 (Sinobiological, 10368-HNAE) or IL1α+IL1β+IL33 at their respective pre-determined EC 80 .

Techniques: Inhibition

Relative mRNA expression of inflammatory genes and levels of cytokines in the lung tissue of rats in each group. (A–D) Relative mRNA expressions of Il6, Il1ra, Il1b , and Plaur of lung tissue in the different groups of rats. (E–L) The levels of IL‐6, IL‐1α, IL‐1β, IL‐12p70, IL‐33, IL‐18, TNF‐α, and KC in lung tissue homogenate of rats in three groups were examined. Six rats per group, and data from each group were repeated three times in each experiment. The data were pooled together for analysis. Room air group ( n = 3–6), hyperoxia group ( n = 4–10), hyperoxia with GB treatment group ( n = 5–13).

Journal: Immunity, Inflammation and Disease

Article Title: Ginkgolide B Alleviates Airway Inflammation in Hyperoxia Lung Injury

doi: 10.1002/iid3.70364

Figure Lengend Snippet: Relative mRNA expression of inflammatory genes and levels of cytokines in the lung tissue of rats in each group. (A–D) Relative mRNA expressions of Il6, Il1ra, Il1b , and Plaur of lung tissue in the different groups of rats. (E–L) The levels of IL‐6, IL‐1α, IL‐1β, IL‐12p70, IL‐33, IL‐18, TNF‐α, and KC in lung tissue homogenate of rats in three groups were examined. Six rats per group, and data from each group were repeated three times in each experiment. The data were pooled together for analysis. Room air group ( n = 3–6), hyperoxia group ( n = 4–10), hyperoxia with GB treatment group ( n = 5–13).

Article Snippet: Rat Interleukin 33, IL‐33 Elisa Kit , CUSABIO , CSB‐E14077r , .

Techniques: Expressing